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Other_recombinant_protein >
Prospec/BIN2 Human/Bridging Integrator 2 Human Recombinant/5µg/PRO-2485-5µg-5µg

Cataloguenumber
PRO-2485
Synonyms
BridgingIntegrator2,BreastCancer-AssociatedProtein1,BreastCancerAssociatedProteinBRAP1,BRAP-1,BRAP1,BIN2.
Introduction
BIN2,alsoknownasBridgingIntegrator2,isacytoplasmicprotein.BIN2comprisesoneBARdomainandInteractswithBIN1.BIN2ishighlyexpressedinsomehematopoietictissues,includingperipheralblood,colon,thymusandplacenta.BIN2stimulatescellmotilityandmigration,mostlikelythroughitsinteractionwiththecellmembraneandwithpodosomeproteinswhichmediateinteractionwiththeCytoskeletonandlikewisemodulatesmembranecurvature&mediatesmembranetubulation.
Description
BIN2producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(1-597a.a.)andfusedtoa6aaHisTagatC-terminuscontainingatotalof606aminoacidsandhavingamolecularmassof66.1kDa.BIN2showsmultiplebandsbetween70-100kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
BIN2proteinsolution(0.25mg/ml)containsPhosphatebufferedsaline(pH7.4),20%glycerol,1mMDTTand0.1mMPMSF.
StABIlity
Purity
Greaterthan80.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPMRGMPGARTSSSGASENHRARGQGGGPQGVGRMAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQLHHHHHH
SafetyDataSheet
SDS