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Prospec/ANG Human, Sf9/ANG Human Recombinant, Sf9/50µg/PRO-2549-50µg-50µg

Cataloguenumber
PRO-2549
Synonyms
Angiogenin,ANG,Ribonuclease5,RNase5,RNASE5,ribonuclease,RNaseAfamily,5,ALS9,HEL168,MGC22466,MGC71966,RNASE4,RAA1.
Introduction
Angiogenin(ANG)isapartoftheRNaseAfamily.ANGisanextremelyeffectivemediatorofnewbloodvesselformation.ANGCleavestRNAwithinanticodonloopsinordertoproducetRNA-derivedstress-inducedfragments(tiRNAs)thatinhibitproteinsynthesisandtriggertheassemblyofstressgranules.ANGisalsostimulatesribosomalRNAsynthesis.TheinteractionwithRNH1invivoregulatestheAngiogenicactivity.
Description
ANGproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining132aminoacids(25-147a.a.)andhavingamolecularmassof15.2kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately13.5-18kDa).ANGisfusedtoa9aminoacidHis-TagatC-terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
ANGproteinsolution(0.25mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRPHHHHHH.
SafetyDataSheet
SDS