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Prospec/ADAM10 Human/A Disintegrin and Metalloproteinase Domain 10 Human Recombinant/2µg/PRO-476-2µg-2µg

Cataloguenumber
PRO-476
Synonyms
Introduction
ADAM10ispartoftheADAMfamilywhicharecellsurfaceproteinswithadistinctivestructurepossessingbothpotentialadhesionandproteasedomains.ADAM10cleavesmanyproteinsincludingTNF-alphaandE-cadherin.ADAM10cleavesthemembrane-boundprecursoroftnf-alphaat76-ala-|-val-77toitsmaturesolubleform.ADAM10isinchargefortheproteolyticreleaseofseveralothercell-surfaceproteins,includingephrin-a2andforconstitutiveandregulatedalpha-secretasecleavageofamyloidprecursorprotein.ADAM10isinvolvedinthenormalcleavageofthecellularprionprotein.ADAM10isinvolvedinthecleavageoftheadhesionmoleculel1atthecellsurfaceandinthereleaseofmembranevesicles,suggestingavesicle-basedproteaseactivity.ADAM10controlstheproteolyticprocessingofnotchandmediateslateralinhibitionduringneurogenesis.
Description
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SafetyDataSheet
SDS