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Prospec/ILK1 Human/Integrin Linked Kinase Human Recombinant/10µg/PKA-353-10µg-10µg
Cataloguenumber
PKA-353
Synonyms
Introduction
ILK1(Integrin-linkedkinase)isaserine/threonineproteinkinase,containing4ankyrin-likerepeats.ILK1regulatesanumberofBIOLOGicalpropertieswhichinclude:anchorage-independentcellcycleprogression,tumorcellinvasionandapoptosis.ILK1canalsobeimplicatedinmediatingcellarchitecture,adhesiontointegrinsubstratesandanchorage-dependentgrowthinepithelialcells.FurThermore,ILK1phosphorylatesbeta-1andbeta-3integrinsubunitonserineandthreonineresidues,butalsoAKT1andGSK3B.ILK1interactswiththecytoplasmicdomainsofintegrin?1and?3subunitsinadditiontoseveraladaptorsandsignalingproteins,italsoactsasaproximalreceptorkinaseregulatingintegrin-mediatedsignaltransduction.ILK1isafocaladhesionproteinpartofthecomplexILK-PINCH.Thiscomplexisdeemedtobeoneoftheconvergencepointsofintegrin-andgrowthfactor-signalingpathway.ILK1isstimulatedrapidlybutbrieflybybothcellfibronectininteractionsinaPI3-K-dependentmanner,probablythroughthebindingofPtdIns(3,4,5)P3withaPH-likedomainofILK.ILK1over-expressionhasbeendocumentedinawidevarietyofhumanmalignancies.
Description
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