>
产品中心 >
Other_enzymes >
Prospec/PTPN11 Human/Protein Tyrosine Phosphatase Non Receptor Type-11 Human Recombinant/1mg/PKA-109-1mg-1mg
Cataloguenumber
PKA-109
Synonyms
ProteinTyrosinePhosphatase,Non-ReceptorType11,Protein-TyrosinePhosphatase1D,Protein-TyrosinePhosphatase2C,EC3.1.3.48,SH-PTP2,SH-PTP3,PTP-1D,PTP-2C,PTP2C,SHP2,Tyrosine-ProteinPhosphataseNon-ReceptorType11,NoonanSyndrome1,METCDS,SHPTP2,BPTP3,SHP-2,JMML,NS1,CFC,PTPN11.
Introduction
Astyrosine-proteinphosphatasenon-receptortype11isoform2(PTPN11),isamemberoftheprotein-tyrosinephosphatasefamily,non-receptorclass2subfamily.PTPN11takespartinsignaltransductionfromthecellsurfacetothenucleusdownstreamofvariouscytosolicproteintyrosinekinasesaswellasreceptors.PTPN11deficientcellshavepoormobilityduetoexcessivephosphorylationofFAKaswellasotherproteinswhichinterferewiththerotationofcellattachmentpointsinthefocaladhesioncomplex.
Description
PTPN11producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining469aminoacids(1-460a.a.)andhavingamolecularmassof53.9kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).PTPN11isexpressedwithan9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
PTPN11proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPMTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCRHHHHHH
SafetyDataSheet
SDS
