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Prospec/GLRX Mouse/Glutaredoxin Mouse Recombinant/20µg/ENZ-1064-20µg-20µg
Cataloguenumber
ENZ-1064
Synonyms
Glutaredoxin-1,Thioltransferase-1,TTase-1,Glrx,Glrx1,Grx,Grx1.
Introduction
GLRX1hasaglutathione-disulfideoxidoreductaseactivityinthepresenceofnadphandglutathionereductase.reduceslowmolecularweightdisulfidesandproteins.Glutaredoxinisaglutathione(GSH)-dependenthydrogendonorforribonucleotidereductaseandalsocatalyzesglutathione-disulfideoxidoreductionreactionsinthepresenceofNADPHandglutathionereductase.GLRX1ismultifunctionalenzymewithglutathione-dependentoxidoreductase,glutathioneperoxidaseandglutathioneS-transferase(GST)activity.Thedisulfidebondfunctionsasanelectroncarrierintheglutathione-dependentsynthesisofdeoxyribonucleotidesbytheenzymeribonucleotidereductase.Inaddition,itisalsoinvolvedinreducingcytosolicprotein-andnon-protein-disulfidesinacoupledsystemwithglutathionereductase.Requiredforresistancetoreactiveoxygenspecies(ROS)bydirectlyreducinghydroperoxidesandforthedetoxificationofROS-mediateddamage.
Description
GLRXMouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining130aminoacids(1-107a.a)andhavingamolecularmassof14.3kDa.GLRXisfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
GLRXproteinsolution(0.5mg/ml)containing20mMMES(pH5.0),20%Glyceroland0.1MNaCl.
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMAQEFVNCKIQSGKVVVFIKPTCPYCRKTQEILSQLPFKQGLLEFVDITATNNTSAIQDYLQQLTGARTVPRVFIGKDCIGGCSDLISMQQTGELMTRLKQIGALQL
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
