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Prospec/OGG1 Mouse/8-Oxoguanine DNA Glycosylase Mouse Recombinant/5µg/ENZ-1048-5µg-5µg
Cataloguenumber
ENZ-1048
Synonyms
HMMH,HOGG1,MUTM,OGH1,APlyase,OGG1,8-OxoguanineDNAGlycosylase,OGG1.
Introduction
OGG1isaDNAglycosylaseenzymewhichtakespartinbaseexcisionrepair.OGG1proteinisthemainenzymeaccountablefortheexcisionof7,8-dihydro-8-oxoguanine(8-oxoG),amutagenicbasebyproductwhicharisesasaresultofexposuretoreactiveoxygenspecies(ROS).OGG1showsbetalyaseactivitythatnicksDNA3tothelesion.
Description
OGG1MouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining368aminoacids(1-345a.a)andhavingamolecularmassof41.3kDa.OGG1isfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
OGG1proteinsolution(0.25mg/ml)containingPhosphateBufferedSaline(pH7.4)and30%glycerol.
StABIlity
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSMLFRSWLPSSMRHRTLSSSPALWASIPCPRSELRLDLVLASGQSFRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDDSQVSRPTLEELETLHKYFQLDVSLAQLYSHWASVDSHFQRVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPNLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQLRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGWHPKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQPSLSREPPAKRKKGSKRPEG.
SafetyDataSheet
SDS