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Prospec/EGFR Human, CHO/Epidermal Growth Factor Receptor, CHO Human Recombinant/1µg/PKA-086-1µg-1µg
Prospec/EGFR Human, CHO/Epidermal Growth Factor Receptor, CHO Human Recombinant/1µg/PKA-086-1µg-1µg
商品编号：
PKA-086-1µg-1µg
品牌：
prospecbio
市场价：
¥1000.00
美元价：
450.00
产品分类：
生长因子
公司分类：
Growth_factor
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Catalogue number
PKA-086
Synonyms
| Epidermal Growth FactorReceptor, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor TyrosineKinase, Proto-Oncogene C-ErbB-1, EC 2.7.10.1, ERBB1, ERBB, HER1, EpidermalGrowth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B)Oncogene Homolog), Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog(Avian), Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog, CellProliferation-Inducing Protein 61, Cell Growth Inhibiting Protein 40, EC 2.7.10,NISBD2, PIG61, MENA. |
Introduction
The epidermal growth factor receptor(EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R(also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), andErbB4 (HER-4). All family members are type I transmembrane glycoprotein thathas an extracellular domain which contains two cysteine-rich domains separatedby a spacer region that is involved in ligand-binding, and a cytoplasmic domainwhich has a membrane-proximal tyrosine kinase domain and a C-terminal tail withmultiple tyrosine autophosphorylation sites. The human EGF R gene encodes a1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide, a621 aa extracellular domain, a 23 aa transmembrane domain, and a 542 aacytoplasmic domain. EGF R has been shown to bind a subset of the EGF familyligands, including EGF, amphiregulin, TGFa , betacellulin, epiregulin,heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligandbinding induces EGF R homodimerization as well as heterdimerization with ErbB2,resulting in kinase activation, tyrosine phosphorylation and cell signaling.EGF R can also be recruited to form heterodimers with the ligand-activatedErbB3 or ErbB4. EGF R signaling has been shown to regulate multiple biologicalfunctions including cell proliferation, differentiation, motility andapoptosis. In addition, EGF R signaling has also been shown to play a role incarcinogenesis.
Description
EGFR produced in CHO cells is a single, glycosylated polypeptide chain containing 860 amino acids (25-645 a.a.) and having a molecular mass of 95.5 kDa (Migrates at 100-150 on SDS-PAGE under reducing conditions). EGFR is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Source
Chinese Hamster Ovary cells.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
| EGFR protein solution (0.25mg/ml)contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greaterthan 90.0% as determined by SDS-PAGE.
Amino acid sequence
| LEEKKVCQGT SNKLTQLGTFEDHFLSLQRM FNNCEVVLGN LEITYVQRNY DLSFLKTIQE VAGYVLIALN TVERIPLENL QIIRGNMYYE NSYALAVLSNYDANKTGLKE LPMRNLQEIL HGAVRFSNNP ALCNVESIQW RDIVSSDFLS NMSMDFQNHL GSCQKCDPSCPNGSCWGAGE ENCQKLTKII CAQQCSGRCR GKSPSDCCHN QCAAGCTGPR ESDCLVCRKF RDEATCKDTCPPLMLYNPTT YQMDVNPEGK YSFGATCVKK CPRNYVVTDH GSCVRACGAD SYEMEEDGVR KCKKCEGPCRKVCNGIGIGE FKDSLSINAT NIKHFKNCTS ISGDLHILPV AFRGDSFTHT PPLDPQELDI LKTVKEITGFLLIQAWPENR TDLHAFENLE IIRGRTKQHG QFSLAVVSLN ITSLGLRSLK EISDGDVIIS GNKNLCYANT INWKKLFGTSGQKTKIISNR GENSCKATGQ VCHALCSPEG CWGPEPRDCV SCRNVSRGRE CVDKCNLLEG EPREFVENSECIQCHPECLP QAMNITCTGR GPDNCIQCAH YIDGPHCVKT CPAGVMGENN TLVWKYADAG HVCHLCHPNCTYGCTGPGLE GCPTNGPKIP SRSPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMISRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKVSNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKTTPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH. |
Safety Data Sheet
SDS
Usage
ProSpec"s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
品牌介绍
ProSpec-Tany TechnoGene Ltd.公司创立人Dr. Tanchum (Tany) Amarant 主要致力于蛋白生物化学方面的研究工作，1947年出生于以色列。1991-1997创建ReProGen 公司，从事细胞因子和趋化因子的大量生产及纯化；1997-2000创建ProSpec-TechnoGene，主要生产用于生命科学研究的各种重组蛋白及相关抗体。拥有专利United States Patent 5434135。
ProSpec is an evolving biotech company providing highly purified proteins worldwide which serve the research community with cytokine-related products for cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cell research.
Among our proteins are Interferons, Interleukins, Bone Morphogenic Proteins, Tumor Necrosis factors, Leptins, Stem Cell factors, Prolactins, Chemokines, Antibodies, Peptides, Enzymes, Viral Antigens, various growth factors such as: Platelet Derived, Epidermal, Insulin Like, Nerve, Connective Tissue, Vascular Endothelial, Fibroblast and more.....
Our research team and scientists have been able to assemble more than 1700 recombinant proteins, peptides and antibodies for your research needs. The proteins are rigorously tested to meet the research and development demand for excellent quality, uncompromising biological activity at competitive prices.
ProSpec has established sterling reputation among the scientific community, a reputation built on innovative products, customer service and attention to detail. Our reputation for quality is an essential factor in achieving a favorable position in the market place and the benefits associated with manufacturing top quality products.
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