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Prospec/GPD2 Human/Glycerol-3-Phosphate Dehydrogenase 2 Human Recombinant/10µg/ENZ-437-10µg-10µg
Cataloguenumber
ENZ-437
Synonyms
Introduction
GPD2(Mitochondrialglycerol-3-phosphatedehydrogenase)isaCa2+-sensitive,FAD-bindingprotein,whichislocatedontheoutersurfaceoftheinnermitochondrialmembrane.TwoisoformshavebeenidentifiedformGPD:Isoform1iscomprisedof727a.a.residues,whileisoform2lacks126a.a.residuesoftheN-terminus.GPD2catalysestheoxidationofglycerol-3-phosphatetoDHAP(dihydroxyacetonephosphate)withassociatedreductionoftheenzyme-boundFAD.GPD2isatestis-specificpromoterofmitochondrialGPDH.GPD2alongwithacytosolicNAD-linkedGPDformstheglycerolphosphateshuttlethatusestheinterconversionofG-3-PandDHAPtotransferreducingequivalentsintomitochondria,whichresultsinthereoxidationofNADHproducedduringglycolysis.GPD2deficiencycontributestotheimpairmentofglucose-stimulatedINSdischargeinanumberofanimalmodelsofnon-INSdependentdiabetesmellitus.GPD2up-regulationasaresultofahighlyglycolyticenvironmentcontributestothegeneralincreaseinROSgenerationandmayleadtotheprogressionofprostatecancer.
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