>
产品中心 >
Other_enzymes >
Prospec/YWHAE人类,His/Tyr-3/Trp-5单加氧酶激活蛋白,ε-人类重组,His标签/2µg/PKA-095-2µg-2µg

Cataloguenumber
PKA-095
Synonyms
YWHAE,MDS,MDCR,KCIP-1,14-3-3E,14-3-3Epsilon,FLJ45465,Tyr-3/Trp-5MonooxygenaseActivationProteinEpsilon,HEL2,KCIP-1,MDCR,MDS.
Introduction
The14-3-3familyofproteinsplaysakeyregulatoryroleinsignaltransduction,checkpointcontrol,apoptoticandnutrient-sensingpathways.14-3-3proteinsarehighlyconservedandubiquitouslyexpressed.Thereareatleastsevenisoforms,β,γ,ε,σ,ζ,τandηthathavebeenidentifiedinmammals.The14-3-3epsilon,asubtypeofthe14-3-3familyofproteins,wasthoughttobebrainandneuron-specific.IthasbeenshowntointeractwithCDC25phosphatases,RAF1andIRS1proteins,suggestingitsroleindiversebiochemicalactivitiesrelatedtosignaltransduction,suchascelldivisionandregulationofinsulinsensitivity.Ithasalsobeenimplicatedinthepathogenesisofsmallcelllungcancer.
Description
YWHAEHumanRecombinantproducedinE.coliisasinglepolypeptidechaincontaining275aminoacids(1-255)andhavingamolecularmassof31.3kDa.YWHAEisfusedtoa20aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TheYWHAEsolution(1mg/1ml)containsphosphatebufferedSaline(pH7.4),1mMDTTand10%glycerol.
StABIlity
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ.
SafetyDataSheet
SDS