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Prospec/YWHAB Human, His/Tyr-3/Trp-5 Monooxygenase Activation Protein, Beta, Human Recombinant, His Tag/5µg/PKA-096-5µg-5µg
Cataloguenumber
PKA-096
Synonyms
14-3-3proteinbeta/alpha,ProteinkinaseCinhibitorprotein1,Protein1054,YWHAB,HS1,GW128,KCIP-1,Tyr-3/Trp-5MonooxygenaseActivationProteinBeta,14-3-3Beta.
Introduction
YWHABbelongstothe14-3-3familyofproteinswhichareinchargeforsignaltransductionbybindingtophosphoserine-containingproteins.YWHABisfoundinbothplantsandmammals.YWHABproteininteractswithRAF1andCDC25phosphatases,thuslinkingmitogenicsignalingandthecellcyclemachinery.YWHABisanadapterproteininvolvedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.YWHABbindstoalargenumberofproteinsbyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner.
Description
YWHABHumanRecombinantproducedinE.coliisasinglepolypeptidechaincontaining270aminoacids(1-246)andhavingamolecularmassof30.6kDa.YWHABisfusedtoa24aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
TheYWHABsolution(1mg/1ml)containsphosphatebufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSHMTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN.
SafetyDataSheet
SDS