
Cataloguenumber
HOR-012
Synonyms
TSHB
Introduction
TSHBisahormonesynthesizedandsecretedbythyrotropecellsintheanteriorpituitaryglandwhichregulatestheendocrinefunctionoftheTgland.Stimulatestheglandtosecretethehormones(T4)andtriiodothyronine(T3).ProductioniscontrolledbyaThyrotropinReleasingHormone,(TRH),whichismanufacturedinthehypothalamusandtransportedtotheAnteriorPituitarygland,whereitincreasesproductionandrelease.Somatostatinisalsoproducedbythehypothalamus,andhasanoppositeeffectonthepituitaryproduction,decreasingorinhibitingitsrelease.ThelevelofThormones(T3andT4)inthebloodhaveanadditionaleffectonthepituitaryreleaseofTSH,WhenthelevelsofT3andT4arelow,theproductionisincreased,andconversely,whenlevelsofT3andT4arehigh,thenproductionisdecreased.Thiseffectcreatesaregulatorynegativefeedbackloop.
Description
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