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Prospec/GDNF Rat/Glial-Derived Neurotrophic Factor Rat Recombinant/1mg/CYT-403-1mg-1mg
Catalogue number
CYT-403
Synonyms
Introduction
GDNF promotes the survival and differentiation of neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.GDNF enhances survival and morphological differentiation of neurons and increases their high-affinity uptake.
Description
Source
Physical Appearance
Formulation
Solubility
It is recommended to reconstitute the lyophilized Glial Derived Neurotrophic Factor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability
Purity
Amino acid sequence
Biological Activity
Safety Data Sheet
SDS