>
产品中心 >
Growth_factor >
Prospec/GDNF Rat/Glial-Derived Neurotrophic Factor Rat Recombinant/10µg/CYT-403-10µg-10µg
Cataloguenumber
CYT-403
Synonyms
Introduction
GDNFpromotesthesurvivalanddifferentiationofneuronsinculture,andisabletopreventapoptosisofmotorneuronsinducedbyaxotomy.Theencodedproteinisprocessedtoamaturesecretedformthatexistsasahomodimer.ThematureformoftheproteinisaligandfortheproductoftheRET(rearrangedduringtransfection)protooncogene.InadditiontothetranscriptencodingGDNF,twoadditionalalternativetranscriptsencodingdistinctproteins,referredtoasastrocyte-derivedtrophicfactors,havealsobeendescribed.MutationsinthisgenemaybeassociatedwithHirschsprungdisease.GDNFenhancessurvivalandmorphologicaldifferentiationofneuronsandincreasestheirhigh-affinityuptake.
Description
Source
PhysicalAppearance
Formulation
Solubility
ItisrecommendedtoreconstitutethelyophilizedGlialDerivedNeurotrophicFactorinsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
StABIlity
Purity
Aminoacidsequence
BIOLOGicalActivity
SafetyDataSheet
SDS