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Prospec/CD276 Human /CD276 Human Recombinant/10µg/PRO-2456-10µg-10µg
Cataloguenumber
PRO-2456
Synonyms
CD276Molecule,CD276Antigen,CostimulatoryMolecule,B7Homolog3,4Ig-B7-H3,B7-H3,B7H3,B7RP-2.
Introduction
CD276,belongstotheB7familyofimmunoregulatorytransmembraneglycoproteinsexpressedbyTcells.CD276isacostimulatorymoleculeforTcellactivationinadditiontoIFN-gammaproduction.FurThermoreCD276upregulatesBRCC3expression,preventingDNAdefectscausedby5-Fu.CD276iscorrelatedwithTNMstageofNSCLCandactasapotentialbioMarkerforNSCLC-derivedMPEs.CD276inhibitsnatural-killermediatedcelllysisintumorcells,andactasamarkerfordetectionofneuroblastomacells.CD276isimplicatedinthedevelopmentofacuteaswellaschronictransplantrejectionandintheregulationoflymphocyticactivityatmucosalsurfaces.Inaddition,CD276providestheplacenta&fetusaproperimmunologicalenvironmentduringthecourseofpregnancy.
Description
CD276HumanRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining446aminoacids(29-466a.a.)andhavingamolecularmassof48.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).CD276isexpressedwithan8aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD276proteinsolution(0.5mg/ml)containsPhosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
LEVQVPEDPVVALVGTDATLCCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYQGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVTITCSSYRGYPEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGSVTITGQPMTFPPEALEHHHHHH.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
