Cataloguenumber
PRO-2501
Synonyms
CD22Molecule,CD22Antigen,SialicAcid-BindingIg-LikeLectin2,B-LymphocyteCellAdhesionMolecule,T-CellSurfaceAntigenLeu-14,SIGLEC-2,SIGLEC2,BL-CAM,SialicAcidBindingIg-LikeLectin2,B-CellReceptorCD22.
Introduction
CD22,alsoknownasSialicAcid-BindingIg-LikeLectin2,ispartoftheimmunoglobulin(Ig)superfamily.CD22mediatesB-celltoB-cellinteractionsandisimplicatedinthelocalizationofB-cellsinlymphoidtissues.CD22actsaspositiveregulatorviainteractionwiththeSrcfamilytyrosinekinases,inadditionCD22preformasaninhibitoryreceptorbyrecruitingcytoplasmicphosphatases.
Description
CD22producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining907aminoacids(20-687a.a.)andhavingamolecularmassof102.1kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately100-150KDa).CD22isexpressedwitha239aminoacidhIgG-His-tagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Formulation
CD22proteinsolution(0.25mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
Greaterthan85.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
DSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS