
Cataloguenumber
PRO-2552
Synonyms
CD19Molecule,B-LymphocyteSurfaceAntigenB4,T-CellSurfaceAntigenLeu-12,DifferentiationAntigenCD19,CD19Antigen,B-LymphocyteAntigenCD19,CVID3,B4.
Introduction
CD19,alsoknownasB-LymphocyteSurfaceAntigenB4,belongstotheIgsuperfamilywhichisexpressedonthesurfaceofallB-lymphoidcellswiththeexceptionofterminallydifferentiatedplasmacells.CD19isinvolvedasasignal-transducingreceptorinthecontrolofdifferentiationaswellasproliferation.CD19isasanadaptorproteinwhichdraftscytoplasmicsignalingproteinstothemembraneandoperateswithintheCD19/CD21complextodecreasethethresholdforBcellreceptorsignalingpathways.CD19ispresentonallBcells,andthereforeisabioMarkerforlymphomadiagnosis,Blymphocytedevelopmentandcanbeusedasatargetforleukemiaimmunotherapies.
Description
CD19producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining510aminoacids(21-291a.a.)andhavingamolecularmassof57.0kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).CD19isexpressedwitha239aminoacidhIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD19proteinsolution(0.25mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan85.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
EEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
SafetyDataSheet
SDS