>
产品中心 >
human_antigen >
Prospec/CD247 Human, Sf9/CD247 Human Recombinant, Sf9/1µg/PRO-2529-1µg-1µg
Cataloguenumber
PRO-2529
Synonyms
CD247Molecule,T-CellSurfaceGlycoproteinCD3ZetaChain,T-CellReceptorT3ZetaChain,CD247Antigen,CD3Z,TCRZ,T3Z,T-CellAntigenReceptorComplex,ZetaSubunitOfCD3,CD3ZAntigen,ZetaPolypeptide(TiT3Complex),CD3zAntigen,ZetaPolypeptide(TiT3Complex),CD247Antigen,ZetaSubunit,TCRZetaChain,CD3zetaChain,CD3-ZETA,IMD25,CD3H,CD3Q.
Introduction
T-cellsurfaceglycoproteinCD3zetachain(CD247)isamemberoftheCD3Z/FCER1Gfamily.CD247isT-cellreceptorzeta,whichalongwithT-cellreceptoralpha/betaandgamma/deltaheterodimers,andalsowithCD3-gamma,-deltaand-epsilon,createstheT-cellreceptor-CD3complex.Thezetachainhasacentralroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.LowexpressionoftheCD247antigencausesimpairedimmuneresponse.
Description
CD247producedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining122aminoacids(52-164a.a.)andhavingamolecularmassof14.1kDa.(MolecularsizeonSDS-PAGEwillappearatapproximately13.5-18kDa).CD247isexpressedwithan9aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
CD247proteinsolution(0.2mg/ml)contains20mMTris-HClbuffer(pH6.8),50%glycerol,1mMDTT,1mMEDTAand0.1MNaCl.
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADPRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPRHHHHHH
SafetyDataSheet
SDS