Cataloguenumber
PRO-2413
Synonyms
Naturalkillercellreceptor2B4,NKcellactivation-inducingligand,NAIL,NKcelltypeIreceptorprotein2B4,NKR2B4,h2B4,SLAMfamilymember4,SLAMF4,Signalinglymphocyticactivationmolecule4,CD244,2B4.
Introduction
ClusterofDifferentiation244(CD244/NaturalKillerCellReceptor2B4)contains2Ig-like(immunoglobulin-like)domains.CD244isacellsurfacereceptorexpressedonnaturalkiller(NK)cells(andsomeTcells)whichmediatenon-majorhistocompatibilitycomplex(MHC)restrictedkilling.NK-cellandtargetcellsinteractionviatheCD244receptorisbelievedtomodulateNK-cellcytolyticactivity.CD244moleculesfunctionineosinophiladhesionandchemotaxis,andhavearoleinthepathophysiologyofallergicrhinitis(AR).
Description
CD244HumanRecombinantproducedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining448aminoacids(19-224a.a.)andhavingamolecularmassof50.2kDa(MolecularsizeonSDS-PAGEwillappearatapproximately50-70kDa).CD244isexpressedwitha239aminoacidshIgG-HistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
PhysicalAppearance
Formulation
CD244proteinsolution(1.0mg/ml)containsPhosphateBufferedSaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan90%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLGKGCQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFRFWPLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH.
SafetyDataSheet
SDS