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Prospec/IP 10 Rat/IP-10 Rat Recombinant (CXCL10)/1mg/CHM-264-1mg-1mg
Cataloguenumber
CHM-264
Synonyms
C-X-Cmotifchemokine10,Gamma-IP10,IP-10,ProteinMob-1,Small-inducIBLecytokineB10,Cxcl10,Inp10,Mob1,Scyb10.
Introduction
Chemokine(C-X-Cmotif)ligand10(CXCL10)isasmallcytokinebelongingtotheCXCchemokinefamily.CXCL10issecretedbyseveralcelltypesinresponsetoIFN-?.Thesecelltypesincludemonocytes,endothelialcellsandfibroblasts.CXCL10hasbeenattributedtoseveralroles,suchaschemoattractionformonocytesandTcells,promotionofTcelladhesiontoendothelialcells,antitumoractivity,andinhibitionofbonemarrowcolonyformationandangiogenesis.ThegeneforCXCL10islocatedonhumanchromosome4inaclusteramongseveralotherCXCchemokines.ThischemokineelicitsitseffectsbybindingtothecellsurfacechemokinereceptorCXCR3.Thethree-dimensionalcrystalstructureofthischemokinehasbeendeterminedunder3differentconditionstoaresolutionofupto1.92A.
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