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Prospec/IP 10 Human/IP-10 Human Recombinant (CXCL10)/1mg/CHM-330-1mg-1mg
Cataloguenumber
CHM-330
Synonyms
SmallinducIBLecytokineB10,CXCL10,10kDa,Gamma-IP10,IP-10,chemokine(C-X-Cmotif)ligand10,C7,IFI10,INP10,crg-2,mob-1,SCYB10,gIP-10.
Introduction
Chemokine(C-X-Cmotif)ligand10(CXCL10)isasmallcytokinebelongingtotheCXCchemokinefamily.CXCL10issecretedbyseveralcelltypesinresponsetoIFN.Thesecelltypesincludemonocytes,endothelialcellsandfibroblasts.CXCL10hasbeenattributedtoseveralroles,suchaschemoattractionformonocytesandTcells,promotionofTcelladhesiontoendothelialcells,antitumoractivity,andinhibitionofbonemarrowcolonyformationandangiogenesis.ThegeneforCXCL10islocatedonhumanchromosome4inaclusteramongseveralotherCXCchemokines.ThischemokineelicitsitseffectsbybindingtothecellsurfacechemokinereceptorCXCR3.Thethree-dimensionalcrystalstructureofthischemokinehasbeendeterminedunder3differentconditionstoaresolutionofupto1.92A.
Description
IP-10HumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechaincontaining77aminoacidsandhavingamolecularmassof8.6kDa.TheIP-10ispurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
Lyophilizedfromasterile(0.2micron)filteredaqueoussolutioncontaining0.1%TrifluoroaceticAcid(TFA).
Solubility
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
SafetyDataSheet
SDS