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Prospec/sRANKL Human, His/Soluble RANK Ligand Human Recombinant, His Tag/5µg/CYT-692-5µg-5µg
Cataloguenumber
CYT-692
Synonyms
SolubleReceptorActivatorofNFkBLigand,TNFSF11,TRANCE,TNF-relatedactivation-inducedcytokine,OPGL,ODF,Osteoclastdifferentiationfactor,Tumornecrosisfactorligandsuperfamilymember11,ReceptoractivatorofnuclearfactorkappaBligand,RANKL,Osteoprotegerinligand,CD254antigen,sRANKL,sOdf,hRANKL2.
Introduction
RANKLbindstotnfrsf11b/opgandtotnfrsf11a/rank.Osteoclastdifferentiationandactivationfactor.AugmentstheABIlityofdendriticcellstostimulatenaivet-cellproliferation.Maybeanimportantregulatorofinteractionsbetweent-cellsanddendriticcellsandmayplayaroleintheregulationofthet-cell-dependentimmuneresponse.sRANKLmayalsoplayanimportantroleinenhancedbone-resorptioninhumoralhypercalcemiaofmalignancy.
Description
sRANKLHumanRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining199aminoacids(140-317a.a)andhavingamolecularmassof22.3kDa.sRANKLisfusedtoa21aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
sRANKLproteinsolution(0.5mg/ml)containing20mMTris-HClbuffer(pH8.0),20%glycerol,0.1MNaCland1mMDTT.
Stability
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID.
SafetyDataSheet
SDS