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Prospec/IFNAR1 Human/Interferon Alpha and Beta Receptor Subunit 1 Human Recombinant/100µg/CYT-1138-100µg-100µg
Cataloguenumber
CYT-1138
Synonyms
IFN-alpha/betaR1,IFNAR1,AVP,IFN-alpha-REC,IFNAR,IFNBR,IFRC,Interferonalpha/betareceptor1,IFN-R-1,IFN-alpha/betareceptor1,Cytokinereceptorclass-IImember1,Cytokinereceptorfamily2member1,CRF2-1,TypeIinterferonreceptor1.
Introduction
InterferonAlphaAndBetaReceptororIFNAR1,ispartoftheclassIIcytokinereceptorfamily.IFNAR1formsoneofthetwochainsofareceptorforinterferonsalphaandbeta.IFNAR1bindsandactivatesthereceptorthatstimulatesJanusproteinkinases,whichthenphosphorylatefewproteins,includingSTAT1&STAT2.FurThermore,IFNAR1alsoactsasanantiviralfactor.
Description
IFNAR1producedinSf9Insectcellsisasingle,glycosylatedpolypeptidechaincontaining415aminoacids(28-436a.a.)andhavingamolecularmassof47.9kDa(MolecularsizeonSDS-PAGEwillappearatapproximately57-70kDa).IFNAR1isexpressedwitha6aminoacidHistagatC-Terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Insectcells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
IFNAR1proteinsolution(0.5mg/ml)containsPhosphateBufferedSaline(pH7.4)and20%glycerol.
StABIlity
Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKHHHHHH.
SafetyDataSheet
SDS
