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Prospec/FGF 2 Mouse/Fibroblast Growth Factor-Basic Mouse Recombinant/1mg/CYT-386-1mg-1mg
Catalogue number
CYT-386
Synonyms
HBGF-2, Prostatropin, FGF-2, FGB-b.
Introduction
FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.The binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.
Description
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References
1.Title: Fibroblast Growth Factor-2 Autofeedback Regulation in PituitaryFolliculostellate TtT/GF CellsPublication: Endocrinology 150.7 (2009): 3252-3258.Link: http://press.endocrine.org/doi/full/10.1210/en.2008-1625
2.Title: The Mouse Cornea as a TransplantationSite for Live Imaging of Engineered Tissue ConstructsPublication: Cold Spring Harbor Protocols 2010.4 (2010):pdb-prot5416.Link:http://cshprotocols.cshlp.org/content/2010/4/pdb.prot5416.full
Safety Data Sheet
SDS