
Cataloguenumber
CYT-500
Synonyms
Introduction
RecombinantIL10isacytokineproducedprimarilybymonocytesandtoalesserextentbylymphocytes.Thiscytokinehaspleiotropiceffectsinimmunoregulationandinflammation.Itdown-regulatestheexpressionofTh1cytokines,MHCclassIIAgs,andcostimulatorymoleculesonmacrophages.ItalsoenhancesBcellsurvival,proliferation,andantibodyproduction.ThiscytokinecanblockNF-kappaBactivity,andisinvolvedintheregulationoftheJAK-STATsignalingpathway.Knockoutstudiesinmicesuggestedthefunctionofthiscytokineasanessentialimmunoregulatorintheintestinaltract.
Description
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References
1.Title:Activatedsignaltransducerandactivatoroftranscription-3(STAT3)isapoorregulatoroftumournecrosisfactor-productionbyhumanmonocytes.Publication:Articlefirstpublishedonline:9JAN2007DOI:10.1111/j.1365-2249.2006.03291.xLink:http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2006.03291.x/full2.Title:Suppressorofcytokinesignalling-3atpathologicallevelsdoesnotregulatelipopolysaccharideorinterleukin-10controloftumournecrosisfactor-?productionbyhumanmonocytes.Publication:Articlefirstpublishedonline:11MAY2006DOI:10.1111/j.1365-2567.2006.02383.xLink:http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2006.02383.x/full3.Title:TheTyrosineSulfate-richDomainsoftheLRRProteinsFibromodulinandOsteoadherinBindMotifsofBasicClustersinaVarietyofHPR-bindingProteins,IncludingBioactiveFactors*.Publication:FirstPublishedonAugust21,2009,doi:10.1074/jbc.M109.047076October16,2009TheJournalofBiologicalChemistry,284,28543-28553.Link:http://www.jbc.org/content/284/42/28543.full
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