
Cataloguenumber
CYT-1047
Synonyms
Interleukin4Receptor,IL-4ReceptorSubunitAlpha,Interleukin13Receptor,IL-4RA,IL4RA,Interleukin-4ReceptorSubunitAlpha,Interleukin-4ReceptorAlphaChain,IL4RNirsVariant1,IL-4RSubunitAlpha,CD124Antigen,IL-4R-Alpha,CD124,IL4R.
Introduction
IL4isapleiotropiccytokineproducedbyactivatedTcells.IL4isaligandforinterleukin4receptor.Theinterleukin4receptoralsobindstoIL13,whichmaycontributetomanyoverlappingfunctionsofthiscytokineandIL13.STAT6,asignaltransducerandactivatoroftranscription,hasbeenshowntoplayacentralroleinmediatingtheimmuneregulatorysignalofthiscytokine.Thisgene,IL3,IL5,IL13,andCSF2formacytokinegeneclusteronchromosome5q,withthisgeneparticularlyclosetoIL13.IL4,IL13andIL5arefoundtoberegulatedcoordinatelybyseverallong-rangeregulatoryelementsinanover120kilobaserangeonthechromosome.Twoalternativelysplicedtranscriptvariantsofthisgeneencodingdistinctisoformshavebeenreported.
Description
IL4RproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(26-232a.a.)andfusedtoan8aaHisTagatC-terminuscontainingatotalof215aminoacidsandhavingamolecularmassof24.7kDa.IL4Rshowsmultiplebandsbetween28-40kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL4Rproteinsolution(0.25mg/ml)containsPhosphatebufferedsaline(pH7.4).
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLEHHHHHH
SafetyDataSheet
SDS