
Cataloguenumber
CYT-1049
Synonyms
Interleukin3ReceptorSubunitAlpha,Interleukin3Receptor,Alpha(LowAffinity),IL-3ReceptorSubunitAlpha,IL-3RSubunitAlpha,CD123Antigen,IL-3R-Alpha,IL-3RA,IL3R,Interleukin-3ReceptorSubunitAlpha,IL-3ReceptorAlphaSP2Isoform,HIL-3Ra,IL3RAY,CD123,IL3RX,IL3RY,IL3RA.
Introduction
IL3RA,alsoknownasInterleukin3ReceptorSubunitAlpha,isasingle-passtype1membraneproteinwhichisamemberofthetype1cytokinereceptorfamilyaswellastype5subfamily.IL3RAisapleiotropiccytokinewhichisproducedmainlybyactivatedTcellsormastcells.Moreover,thespecificalphasubunitoftheinterleukin3receptorisstronglyexpressedinavarietyofleukemicblastsaswellasleukemicstemcellsandappearstobeagreattargetforthetherapyofleukemias.
Description
IL3RAproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechain(20-305a.a.)andfusedtoa6aaHisTagatC-terminuscontainingatotalof295aminoacidsandhavingamolecularmassof34.1kDa.IL3RAshowsmultiplebandsbetween40-57kDaonSDS-PAGE,reducingconditionsandpurifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL3RAproteinsolution(0.5mg/ml)contains10%glycerol&Phosphatebufferedsaline(pH7.4).
StABIlity
Purity
Greaterthan90.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
ADLKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRHHHHHH.
SafetyDataSheet
SDS