Cataloguenumber
CYT-1016
Synonyms
IL-31,Interleukin31,IL31.
Introduction
IL-31producedbyactivatedTh2-typeTcells,cooperateswithaheterodimericreceptorconsistingofIL-31ReceptorAnatagoNISTandOnconstatin-MReceptorthatiscontinueslyexpressedonepithelialcellsandkeratinocytes.IL-31playsaroleinthepromotionofallergicskindisordersandinregulatingotherallergicdiseases,suchasasthma.IL-31isinvolvedintheitchingsensationandendorsesthescratchingbehaviorinNC/Ngamicewithatopicdermatitis.IL-31expressionisconnectdwithCLA(+)Tcellsandcontributestothedevelopmentofatopicdermatitis-inducedskininflammationandpruritus.IL-31isapowerfulinducerofproinflammatorymediatorsinhumancolonicSEMFs.IL-31takespartasaproinflammatorycytokinederivedfromTh2cells.SerumIL-31levelishigherinpatientswithatopicdermatitis.IL-31isinvolvedinabroadrangeofimmune-&non-immunecells&possessespotentialpleiotropicphysiologicalfunctions,includingregulatinghematopoiesis&immuneresponse,causinginflammatoryboweldisease,airwayhypersensitivity&dermatitis.
Description
IL31CanineRecombinantproducedinSf9Baculoviruscellsisasingle,glycosylatedpolypeptidechaincontaining142aminoacids(24-159a.a.)andhavingamolecularmassof16.1kDa(MolecularsizeonSDS-PAGEwillappearatapproximately18-28kDa).IL31isfusedtoa6aminoacidHis-TagatC-terminusandpurifiedbyproprietarychromatographictechniques.
Source
Sf9,Baculoviruscells.
PhysicalAppearance
Sterilefilteredcolorlesssolution.
Formulation
IL31Canineproteinsolution(1mg/ml)containingPhosphatebufferedsaline(pH7.4)and10%glycerol.
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
SHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQHHHHHH.
SafetyDataSheet
SDS
