
Cataloguenumber
CYT-1100
Synonyms
Interleukin-1alpha,IL-1alpha.
Introduction
IL-1alphaisproducedbyactivatedmacrophages.IL-1alphastimulatesthymocyteproliferationbyinducingil-2release,b-cellmaturationandproliferation,andfibroblastgrowthfactoractivity.IL1Aproteinstakepartintheinflammatoryresponse,beingidentifiedasendogenouspyrogens,andstimulatethereleaseofprostaglandinandCollagenasefromsynovialcells.
Description
IL1ARatRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining179aminoacids(115-270a.a)andhavingamolecularmassof20.2kDa.IL1Aisfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.
Source
PhysicalAppearance
Formulation
IL1Aproteinsolution(1mg/ml)contains10%glycerol&PhosphateBufferedSaline(pH7.4).
StABIlity
Purity
BIOLOGicalActivity
TheED50thatwasmeasuredinacellproliferationassayusingD10.G4.1mousehelperTcellis<20pg/ml.
Aminoacidsequence
MGSSHHHHHHSSGLVPRGSHMGSSAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASLNDLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETPKLITGSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSMIDFQIS.
SafetyDataSheet
SDS