
Cataloguenumber
CYT-050
Synonyms
Introduction
IL23iscomposedofasubunitoftheheterodimericcytokineIL23andthep40subunitofinterleukin12(IL12B).Interleukin-23(IL-23)belongstotheIL-12familyandisproducedbyantigenpresentingcells.IL-23usingIL12RB1andIL-23R(specificforIL-23)canactivateSTATandNF-kBpathwaysandstimulatetheproductionofIFN-gamma.).IL-23isknowntotakeavitalpartintheinflammationprocessandisassociatedwithautoimmunediseases.However,unlikeIL12,whichactsprimarilyonnaiveCD4(+)Tcells,IL23preferentiallyactsonmemoryCD4(+)Tcells.
Description
Source
PhysicalAppearance
Formulation
IL-23waslyophilizedfroma0.1µmfilteredsolution(1.05mg/ml)containing1xPBS.
Solubility
ItisrecommendedtoreconstitutethelyophilizedIL23insterile1xPBScontaining0.1%endotoxin-freerecombinantHSA.
StABIlity
Purity
BIOLOGicalActivity
Theactivity,asdeterminedbythedosedependentsecretionofIL-17inresponsetoIL-23usingmurinesplenocytes,theED50is1.9ng/ml.
SafetyDataSheet
SDS