Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1B proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin from synovial cells.

SDS

1. Title:Proinflammatory Cytokine IL-1b Stimulates IL-8 Synthesis in Mast Cells via a Leukotriene B4 Receptor 2-Linked Pathway, Contributing to Angiogenesis.Publication:Published online before print March 1, 2010, doi: 10.4049/ jimmunol.0901735 The Journal of Immunology April 1, 2010 vol. 184 no. 7 3946-3954.Link:http://www.jimmunol.org/content/184/7/3946.fullApplication:Level of IL-8 mRNA was dramatically enhanced by IL-1b,HMC-1 cells were stimulated with IL-1b.

2.Title:Contribution of IL-1 to resistance toStreptococcus pneumoniaeinfection .Publication: Int. Immunol. (2008) 20 (9): 1139-1146. doi: 10.1093/intimm/dxn071 First published online: July 1, 2008Link:http://intimm.oxfordjournals.org/content/20/9/1139.full3.Title:Hydrogen sulphide decreases IL-1b induced activation of fibroblast?like synoviocytes from patients with osteoarthritisPublications:journal of cellular and molecular medicine 19.1 (2015): 187-197Link:http://onlinelibrary.wiley.com/doi/10.1111/jcmm.12405/epdf

4.Title:Riampin Augments Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial CellsPublications:Antimicrobial agents and chemotherapy 50.1 (2006): 396-398Link:http://aac.asm.org/content/50/1/396.full

5.Title:Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediatorsPublication:Arthritis Res Ther11.6 (2009): R161.Link:http://www.biomedcentral.com/content/pdf/ar2844.pdf