
Cataloguenumber
CYT-236
Synonyms
LeukocyteIFN,BcellIFN,TypeIIFN,IFNB1,IFB,IFF,IFNB,IFN-b1a,MGC96956.
Introduction
IFN-betahasantiviral,antibacterialandanticanceractivities.
Description
IFN-beta1aHumanRecombinantproducedinCHO(ChineseHamsterOvarian)cellsisasingle,glycosylatedpolypeptidechaincontaining166aminoacidsandhavingamolecularmassof22500Dalton.IFN-beta1aispurifiedbyproprietarychromatographictechniques.
Source
Formulation
Lyophilizedfromasolutioncontaining91mgHumanAlbumin,and620mgmannitoland50mMAcetateacidpH3.8.
Solubility
ItisrecommendedtoreconstitutethelyophilizedIFNbeta1ainsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.
StABIlity
LyophilizedIFN-beta1aalthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionIFN-Beta1ashouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Pleasepreventfreeze-thawcycles.
Purity
BIOLOGicalActivity
Usage
SafetyDataSheet
SDS
References
Title:IFNGinducesapoptosisinhumanSH-SY5YneuroblastomacellsthroughactivationofJAK–STATsignalinganddown-regulationofPI3K/Aktpathway.Publication:Articlefirstpublishedonline:11NOV2010DOI:10.1111/j.1471-4159.2010.07046.xLink:http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.07046.x/full