
Cataloguenumber
CYT-1028
Synonyms
NatriureticpeptidesA,CDD-ANF,Cardiodilatin,CDD,Cardiodilatin-relatedpeptide,CDP,N-terminalproatrialnatriureticpeptide,ANP,PND.
Introduction
NatriureticPeptideA(NPPA)isapartofthenatriureticpeptidefamilyandisinvolvedincardiovascularhomeostasisthroughregulationofnatriuresis,diuresis,andvasodilation.NPPAissynthesizedasagreatprecursorwhichreleasesapeptidefromtheN-terminuswithsimilaritytovasoactivepeptide,cardiodilatin,andanotherpeptidefromtheC-terminuswithnatriuretic-diureticactivity.Infemalepregnancy,NPPAispromotingtrophoblastinvasionandspiralarteryremodelinginuterus.
Description
NPPAHumanRecombinantproducedinE.Coliisasingle,non-glycosylated,polypeptidechain(a.a26-123)containing106aminoacidsincludingan8a.aN-terminalHistag.Thetotalmolecularmassis11.7kDa(calculated).
Source
PhysicalAppearance
Formulation
NPPAfiltered(0.4µm)andlyophilizedfrom0.5mg/mlin20mMTrisbuffer,50mMNaCland5%w/vtrehalosa,pH7.5.
Solubility
Itisrecommendedtoadddeionizedwatertoprepareaworkingstocksolutionofapproximately0.5mg/mlandletthelyophilizedpelletdissolvecompletely.NPPAisnotsterile!Pleasefiltertheproductbyanappropriatesterilefilterbeforeusingitinthecellculture.
StABIlity
Purity
Greaterthan95.0%asdeterminedbySDS-PAGE.
Aminoacidsequence
MKHHHHHHNPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPR.
SafetyDataSheet
SDS
Usage
Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theymaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.